Original Research

Serum prostate specific antigen is a good indicator of prostatic volume in men with benign prostatic hyperplasia

Ebenezer Abotsi, Kekeli K. Adanu, Eyram C. Bansah
African Journal of Primary Health Care & Family Medicine | Vol 14, No 1 | a3736 | DOI: https://doi.org/10.4102/phcfm.v14i1.3736 | © 2022 Ebenezer Abotsi, Kekeli K. Adanu, Eyram C. Bansah | This work is licensed under CC Attribution 4.0
Submitted: 06 July 2022 | Published: 15 December 2022

About the author(s)

Ebenezer Abotsi, Department of Obstetrics and Gynaecology, Ho Teaching Hospital, Ho, Ghana
Kekeli K. Adanu, Department of Surgery, School of Medicine, University of Health and Allied Sciences, Ho, Ghana
Eyram C. Bansah, Department of Surgery, Richard Novati Catholic Hospital, Sogakope, Ghana


Background: Benign prostatic hyperplasia (BPH) is the most common cause of bladder outlet obstruction in men over the age of 50 years. An association between the prostate specific antigen (PSA), International Prostate Symptoms Score (IPSS) and prostate volume (PV) may be instrumental in determining patients who may benefit from treatment. Targeted therapy will reduce the cost of care because it is unwise to treat all men with prostate enlargement to prevent complications when the risk of occurrence is negligible.

Aim: To determine the correlation between the PSA, IPSS and PV in men of African descent.

Setting: This was a cross sectional analysis involving 92 patients diagnosed as having symptomatic BPH at the Ho Teaching Hospital.

Methods: The data were collected using standardised questionnaires. The IPSS determined urinary symptom severity. The PV was determined using a transabdominal ultrasound machine. Serum PSA was retrieved from the electronic medical records.

Results: The mean PV was 61.04 cm3 ± 21.95 cm3, the mean PSA was 4.21 ng/mL ± 3.85 ng/mL, and mean IPSS of 21.59 ± 3.78. The Pearson’s correlation between PV and PSA was 0.283 (p = 0.01), between PV and IPSS was 0.108 (p = 0.30), and finally, between Serum PSA and IPSS Score was −0.086 (p = 0.42).

Conclusion: This study showed that serum PSA has a positive correlation with PV. However, IPSS had no significant association with PSA or PV in patients with BPH.

Contribution: This study provides insights into the implications of clinical parameters on the management of prostate enlargement.


correlation; prostate volume; symptom severity; PSA; benign prostatic hyperplasia.


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