Original Research

Low dose Mifepristone (100 mg) for medical termination of pregnancy

Shikha Seth, Arun Nagrath, Neeru Goel
African Journal of Primary Health Care & Family Medicine | Vol 3, No 1 | a254 | DOI: https://doi.org/10.4102/phcfm.v3i1.254 | © 2011 Shikha Seth, Arun Nagrath, Neeru Goel | This work is licensed under CC Attribution 4.0
Submitted: 11 November 2010 | Published: 08 September 2011

About the author(s)

Shikha Seth, Department of Obstetrics & Gynaecology, U.P. Rural Institute of Medical Sciences & Research Saifai, Etawah, India
Arun Nagrath, Department of Obstetrics & Gynaecology, U.P. Rural Institute of Medical Sciences & Research Saifai, Etawah, India
Neeru Goel, Department of Obstetrics & Gynaecology, Era’s Medical College, Sarfarazganj, Lucknow, India


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Abstract

Background: Abortion is the most common entity in the practice of obstetrics and gynaecology. Different methods and modes have been opted for until now to find an effective regimen with the least complications. We have tried the minimal dose (100 mg) of Mifepristone (PO) instead of the presently recommended 200 mg for medical abortion in early first trimester cases.

Objectives: The objective of the study was to determine the efficacy of low dose (100 mg) Mifepristone for medical termination of early pregnancy with oral Misoprostol 800 μg, 24 hours later.

Design: A prospective analytical study was conducted on a population of 82 early-pregnant patients who have requested medical abortions.

Method: Pregnant women of less than 56 days gestation age from their last menstrual period, requesting medical abortion were selected over a period of 14 months from January 2007 to March 2008. They were given 100 mg Mifepristone orally on Day-1, followed by 800 μg Misoprostol orally 24 hours later on Day-2, keeping the patient in the ward for at least 6 hours. Abortion interval, success rate, post-abortion bleeding and side-effects were noted. Success was defined as complete uterine evacuation without the need for surgical intervention.

Results: The total success rate of this minimal dose Mifepristone regimen was 96.25%. Pain and nausea were the predominant side-effects noted. In total 72 (90%) women had completely aborted within 5 hours of taking Misoprostol. Three (3.75%) women only required suction aspiration, hence termed as failed medical abortion. The abortion interval increased with the gestation age. All three failures were of the more-than-42-day gestational age group. The overall mean abortion interval was 4.68 ± 5.32 hours.

Conclusion: Mifepristone 100 mg, followed 24 hours later by Misoprostol 800 μg orally, is a safe and effective regimen for medical abortion.


Keywords

anti-Progesterone; abortion interval; medical abortion; Mifepristone (RU 486); Misoprostol

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